Here's the distinction. creativehub is theprintspace's fulfilment platform for prints — Giclée and C-Type fine-art prints, plus pre-made frames — produced on demand and shipped worldwide. So anything you sell as a print product can be set up, sold and automatically fulfilled through your connected store.
What isn't fulfilled is original artwork — a one-of-a-kind painting, drawing or physical original is a sale and a shipment between you and your buyer, outside the print-on-demand service.
The good news is these two can usually live together. Your store (Shopify, Etsy, Squarespace, WooCommerce, and others) is yours to arrange as you like — you control product listings, descriptions, images and prices. Many artists list originals alongside print editions of the same or different works in a single shop. The practical rule is simply that the print products connected to creativehub keep their SKUs intact so they can be fulfilled automatically, while your originals are handled and shipped by you.